Journal
PHYSIOLOGY
Volume 27, Issue 1, Pages 43-52Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00034.2011
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Funding
- National Heart, Lung, and Blood Institute [HL-108186, HL-103205, HL098954]
- AHA
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Cell death is regulated by a myriad of intracellular molecular pathways, with many involving protein phosphorylation and dephosphorylation. In this review, we will focus on Ser/Thr phosphatases-mediated regulation in cell apoptosis as well as on their potential roles in cell necrosis. The emerging functional importance of Ser/Thr protein phosphatases in cell death regulation adds new dimension to the signaling mechanisms of cellular function, physiology, and diseases.
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