Journal
PHYSIOLOGY
Volume 26, Issue 4, Pages 252-265Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00005.2011
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Ion channels and G-protein-coupled receptors (GPCRs) play a fundamental role in cancer progression by influencing Ca2+ influx and signaling pathways in transformed cells. Transformed cells thrive in a hostile environment that is characterized by extracellular acidosis that promotes the pathological phenotype. The pathway(s) by which extracellular protons achieve this remain unclear. Here, a role for proton-sensing ion channels and GPCRs as mediators of the effects of extracellular protons in cancer cells is discussed.
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