Journal
PHYSIOLOGY
Volume 26, Issue 6, Pages 424-437Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00029.2011
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Funding
- Fondation pour la Recherche Medicale
- Agence Nationale pour la Recherche
- CNRS
- Region Provence Cote d'Azur
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Background K-2P channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K-2P channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K-2P channels.
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