Journal
PHYSIOLOGY
Volume 25, Issue 3, Pages 186-198Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00005.2010
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- German Research Foundation [Li 690/7-2 (KFO 155)]
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The giant muscle protein titin, the backbone of the sarcomere, harbors a complex molecular spring whose stiffness is variably tuned in health and disease. Titin is increasingly recognized as a crucial integrator of diverse myocyte signaling pathways. The titin-associated signalosome includes hotspots of protein-protein interactions important for the regulation of protein quality-control mechanisms, hypertrophic gene activation, and mechanosensing.
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