Journal
PHYSIOLOGY
Volume 25, Issue 1, Pages 27-40Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00039.2009
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Funding
- National Heart, Lung, and Blood Institute [HL-61437]
- National Science Foundation
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The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.
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