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Rho Signaling and Tight Junction Functions

Journal

PHYSIOLOGY
Volume 25, Issue 1, Pages 16-26

Publisher

AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00034.2009

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Funding

  1. Fight for Sight
  2. Association for International Cancer Research
  3. Biotechnology and Biological Sciences Research Council
  4. Medical Research Council
  5. Wellcome Trust
  6. Biomedical Research Centre for Ophthalmology
  7. Biotechnology and Biological Sciences Research Council [BB/H002294/1] Funding Source: researchfish
  8. Medical Research Council [G0900098, G0400678, G0700743] Funding Source: researchfish
  9. BBSRC [BB/H002294/1] Funding Source: UKRI
  10. MRC [G0400678, G0900098, G0700743] Funding Source: UKRI

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Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease.

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