Journal
PHYSIOLOGY
Volume 24, Issue 1, Pages 8-16Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00035.2008
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Funding
- National Institutes of Health [NS-36251, DA-018343, MSTP TG 5T32 GM-07205]
- G. Harold and Leila Y. Mathers Charitable Foundation
- Lowe Syndrome Association
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Phosphoinositides are implicated in the regulation of a wide variety of cellular functions. Their importance in cellular and organismal physiology is underscored by the growing number of human diseases linked to perturbation of kinases and phosphatases that catalyze interconversion from one phosphoinositide to another. Many such enzymes are attractive targets for therapeutic interventions. Here, we review diseases linked to inheritable or somatic mutations of these enzymes.
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