Journal
PHYSIOLOGY
Volume 24, Issue 5, Pages 307-316Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00018.2009
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Funding
- NIDCD NIH HHS [R01 DC001098] Funding Source: Medline
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC001098] Funding Source: NIH RePORTER
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Sensory transduction in the cochlea and vestibular labyrinth depends on fluid movements that deflect the hair bundles of mechanosensitive hair cells. Mechanosensitive transducer channels at the tip of the hair cell stereocilia allow K+ to flow into cells. This unusual process relies on ionic gradients unique to the inner ear. Linking genes to deafness in humans and mice has been instrumental in identifying the ion transport machinery important for hearing and balance. Morphological analysis is difficult in patients, but mouse models have helped to investigate phenotypes at different developmental time points. This review focuses on cellular ion transport mechanisms in the stria vascularis that generate the major electrochemical gradients for sensory transduction.
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