Journal
PHYSIOLOGY
Volume 23, Issue 2, Pages 64-74Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00040.2007
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Accumulating data are documenting an inverse relationship between immune status, response to vaccination, health, and longevity, suggesting that the immune system becomes less effective with advancing age and that this is clinically relevant. The mechanisms and consequences of age-associated immune alterations, designated immunosenescence, are briefly reviewed here.
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