Journal
PHYSIOLOGY
Volume 23, Issue 3, Pages 151-159Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00043.2007
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Funding
- NHLBI NIH HHS [R01 HL-70250, R01 HL-62494, HL-007121, R01 HL-079031] Funding Source: Medline
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The multifunctional Ca2+/calmodulin- dependent protein kinase II ( CaMKII) regulates a rich variety of downstream targets in heart. Ca2+ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.
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