Journal
PHYSIOLOGY
Volume 23, Issue 4, Pages 194-204Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00009.2008
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The presenilins in combination with other proteins generate different gamma-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer's disease and cancer. Presenilins appear also to exert additional functions outside of the gamma-secretase quartets, which needs further investigation.
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