Journal
PHYSIOLOGICAL REVIEWS
Volume 94, Issue 2, Pages 383-417Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physrev.00019.2013
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Funding
- National Institutes of Health Grants [AR053851, CA131974]
- Bayer Healthcare System (Grants4Targets) and SK Agarwal donor funds
- Canadian Institutes of Health Research Grants [MOP-119103, NHG-107768, IMH89827]
- American Heart Association
- [AR057126]
- [HL093305]
- [DK071920]
- [NS0065825]
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Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review highlights the mechanism of action of these proteins with respect to their structure, impact on cell differentiation and survival, role in cancer development and progression, and function in signal transduction. We also discuss the mechanisms whereby TG level is controlled and how TGs control downstream targets. The studies described herein begin to clarify the physiological roles of TGs in both normal biology and disease states.
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