Related references
Note: Only part of the references are listed.Patch-clamp amplifiers on a chip
Pujitha Weerakoon et al.
JOURNAL OF NEUROSCIENCE METHODS (2010)
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism
Yves Bourne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Design and expression of human α7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties
Marios Zouridakis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)
Single-Channel Current Through Nicotinic Receptor Produced by Closure of Binding Site C-Loop
Hai-Long Wang et al.
BIOPHYSICAL JOURNAL (2009)
Biophysics and Structure of the Patch and the Gigaseal
Thomas M. Suchyna et al.
BIOPHYSICAL JOURNAL (2009)
Decremental Response to High-Frequency Trains of Acetylcholine Pulses but Unaltered Fractional Ca2+ Currents in a Panel of Slow-Channel Syndrome Nicotinic Receptor Mutants
Sergio Elenes et al.
JOURNAL OF GENERAL PHYSIOLOGY (2009)
Binding to Gating Transduction in Nicotinic Receptors: Cys-Loop Energetically Couples to Pre-M1 and M2-M3 Regions
Won Yong Lee et al.
JOURNAL OF NEUROSCIENCE (2009)
Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors
Diego Rayes et al.
JOURNAL OF NEUROSCIENCE (2009)
Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors
Remigijus Lape et al.
JOURNAL OF PHYSIOLOGY-LONDON (2009)
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
Ricarda J. C. Hilf et al.
NATURE (2009)
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
Nicolas Bocquet et al.
NATURE (2009)
Detection and trapping of intermediate states priming nicotinic receptor channel opening
Nuriya Mukhtasimova et al.
NATURE (2009)
Inhibition mechanism of the acetylcholine receptor by α-neurotoxins as revealed by normal-mode dynamics
Abraham O. Samson et al.
BIOCHEMISTRY (2008)
An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance
Scott B. Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Congenital myasthenia-related AChR δ subunit mutation interferes with intersubunit communication essential for channel gating
Xin-Ming Shen et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
Ricarda J. C. Hilf et al.
NATURE (2008)
Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer
Gisela D. Cymes et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Control of cation permeation through the nicotinic receptor channel
Hai-Long Wang et al.
PLOS COMPUTATIONAL BIOLOGY (2008)
Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore
Todd T. Talley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Acetylcholine receptor gating at extracellular transmembrane domain interface: the Pre-M1 linker
Prasad Purohit et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
Acetylcholine receptor gating:: Movement in the α-subunit extracellular domain
Prasad Purohit et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
Acetylcholine receptor gating at extracellular transmembrane domain interface: the Cys-loop and M2-M3 linker
Archana Jha et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
The conformation of acetylcholine at its target site in the membrane-embedded nicotinic acetylcholine receptor
P. T. F. Williamson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Crystal structure of the extracellular domain of nAChR α1 bound to α-bungarotoxin at 1.94 A resolution
Cosma D. Dellisanti et al.
NATURE NEUROSCIENCE (2007)
Conformational dynamics of the αM3 transmembrane helix during acetylcholine receptor channel gating
David J. Cadugan et al.
BIOPHYSICAL JOURNAL (2007)
An intersubunit trigger of channel gating in the muscle nicotinic receptor
Nuriya Mukhtasimova et al.
JOURNAL OF NEUROSCIENCE (2007)
Chain length dependence of the interactions of bisquaternary ligands with the Torpedo nicotinic acetylcholine receptor
Chris R. J. Carter et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor
Amanda L. Cashin et al.
BIOCHEMISTRY (2007)
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family
Nicolas Bocquet et al.
NATURE (2007)
The therapy of congenital myasthenic syndromes
Andrew G. Engel
NEUROTHERAPEUTICS (2007)
Solution NMR of acetylcholine binding protein reveals agonist-mediated conformational change of the C-loop
Fan Gao et al.
MOLECULAR PHARMACOLOGY (2006)
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors
Xiaolin Cheng et al.
PLOS COMPUTATIONAL BIOLOGY (2006)
Ligand-induced conformational changes in the acetylcholine-binding protein analyzed by hydrogen-deuterium exchange mass spectrometry
JX Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Recent advances in Cys-loop receptor structure and function
SM Sine et al.
NATURE (2006)
Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP
C Ulens et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Channel opening motion of α7 nicotinic acetylcholine receptor as suggested by normal mode analysis
XL Cheng et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
LGICdb: a manually curated sequence database after the genomes
Marco Donizelli et al.
NUCLEIC ACIDS RESEARCH (2006)
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors
XN Xiu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Probing ion-channel pores one proton at a time
GD Cymes et al.
NATURE (2005)
Elastic network models for understanding biomolecular machinery: From enzymes to supramolecular assemblies
C Chennubhotla et al.
PHYSICAL BIOLOGY (2005)
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
WY Lee et al.
NATURE (2005)
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
SB Hansen et al.
EMBO JOURNAL (2005)
Dynamics of the acetylcholine receptor pore at the gating transition state
A Mitra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Photolabeling the Torpedo nicotinic acetylcholine receptor with 4-azido-2,3,5,6-tetrafluorobenzoylcholine, a partial agonist
S Nirthanan et al.
BIOCHEMISTRY (2005)
Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors
PHN Celie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor
N Mukhtasimova et al.
JOURNAL OF GENERAL PHYSIOLOGY (2005)
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant
PHN Celie et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
A Taly et al.
BIOPHYSICAL JOURNAL (2005)
A gating mechanism proposed from a simulation of a human α7 nicotinic acetylcholine receptor
RJ Law et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake α-neurotoxins and nicotinic receptors
Y Bourne et al.
EMBO JOURNAL (2005)
Ligand-induced conformational change in the α7 nicotinic receptor ligand binding domain
RH Henchman et al.
BIOPHYSICAL JOURNAL (2005)
Refined structure of the nicotinic acetylcholine receptor at 4 Å resolution
N Unwin
JOURNAL OF MOLECULAR BIOLOGY (2005)
Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence
F Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
BioMOCA - a Boltzmann transport Monte Carlo model for ion channel simulation
TA van der Straaten et al.
MOLECULAR SIMULATION (2005)
Gating dynamics of the acetylcholine receptor extracellular domain
S Chakrapani et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures
PHN Celie et al.
NEURON (2004)
Soluble, oligomeric, and ligand-binding extracellular domain of the human α7 acetylcholine receptor expressed in yeast -: Replacement of the hydrophobic cysteine loop by the hydrophilic loop of the ACh-binding protein enhances protein solubility
V Avramopoulou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays
ML Tierney et al.
JOURNAL OF EXPERIMENTAL BIOLOGY (2004)
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
C Bouzat et al.
NATURE (2004)
Single-channel behavior of heteromeric α1β glycine receptors:: An attempt to detect a conformational change before the channel opens
V Burzomato et al.
JOURNAL OF NEUROSCIENCE (2004)
Invariant aspartic acid in muscle nicotinic receptor contributes selectively to the kinetics of agonist binding
WY Lee et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
The influence of geometry, surface character, and flexibility on the permeation of ions and water through biological pores
O Beckstein et al.
PHYSICAL BIOLOGY (2004)
Structure and function of glutamate receptor ion channels
ML Mayer et al.
ANNUAL REVIEW OF PHYSIOLOGY (2004)
Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating
A Mitra et al.
STRUCTURE (2004)
Free-energy landscapes of ion-channel gating are malleable: Changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels
C Grosman
BIOCHEMISTRY (2003)
The role of loop 5 in acetylcholine receptor channel gating
S Chakrapani et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain
HL Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors
SP Kelley et al.
NATURE (2003)
Structure and gating mechanism of the acetylcholine receptor pore
A Miyazawa et al.
NATURE (2003)
Curariform antagonists bind in different orientations to acetylcholine-binding protein
F Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
X-ray structure of a voltage-dependent K+ channel
YX Jiang et al.
NATURE (2003)
Sleuthing molecular targets for neurological diseases at the neuromuscular junction
AG Engel et al.
NATURE REVIEWS NEUROSCIENCE (2003)
Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant εL221F, inferred from maximum likelihood fits
CJ Hatton et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
Asymmetric structural motions of the homomeric alpha 7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation
RH Henchman et al.
BIOPHYSICAL JOURNAL (2003)
The nicotinic receptor ligand binding domain
SM Sine
JOURNAL OF NEUROBIOLOGY (2002)
Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein
SB Hansen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Naturally occurring mutations at the acetylcholine receptor binding site independently alter ACh binding and channel gating
SM Sine et al.
JOURNAL OF GENERAL PHYSIOLOGY (2002)
Molecular dynamics simulations of biomolecules
M Karplus et al.
NATURE STRUCTURAL BIOLOGY (2002)
Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain
SM Sine et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The mechanism for acetylcholine receptor inhibition by α-neurotoxins and species-specific resistance to α-bungarotoxin revealed by NMR
AO Samson et al.
NEURON (2002)
Residues in the ε subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the α-ε subunit interface site
BE Molles et al.
BIOCHEMISTRY (2002)
Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the a subunits
N Unwin et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Structure of the transition state of gating in the acetylcholine receptor channel pore:: A Π-value analysis
GD Cymes et al.
BIOCHEMISTRY (2002)
Applying hidden Markov models to the analysis of single ion channel activity
L Venkataramanan et al.
BIOPHYSICAL JOURNAL (2002)
A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase
CK Vaughan et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2002)
Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites
N Le Novère et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Identification of residues at the α and ε subunit interfaces mediating species selectivity of Waglerin-1 for nicotinic acetylcholine receptors
BE Molles et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
NMR structure of α-bungarotoxin free and bound to a mimotope of the nicotinic acetylcholine receptor
M Scarselli et al.
BIOCHEMISTRY (2002)
Emerging structure of the nicotinic acetylcholine receptors
A Karlin
NATURE REVIEWS NEUROSCIENCE (2002)
Water conduction through the hydrophobic channel of a carbon nanotube
G Hummer et al.
NATURE (2001)
The binding site of acetylcholine receptor as visualized in the X-ray structure of a complex between α-bungarotoxin and a mimotope peptide
M Harel et al.
NEURON (2001)
Aromatics at the murine nicotinic receptor agonist binding site:: mutational analysis of the αY93 and αW149 residues
G Akk
JOURNAL OF PHYSIOLOGY-LONDON (2001)
Nicotinic receptors in wonderland
T Grutter et al.
TRENDS IN BIOCHEMICAL SCIENCES (2001)
The solution structure of the complex formed between α-bungarotoxin and an 18-mer cognate peptide derived from the α1 subunit of the nicotinic acetylcholine receptor from Torpedo californica
HY Zeng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
K Brejc et al.
NATURE (2001)
A glia-derived acetylcholine-binding protein that modulates synaptic transmission
AB Smit et al.
NATURE (2001)
Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist
D Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels -: A single-channel study of second transmembrane segment 12′ mutants
C Grosman et al.
JOURNAL OF GENERAL PHYSIOLOGY (2000)
Pairwise electrostatic interactions between α-neurotoxins and γ, δ, and ε subunits of the nicotinic acetylcholine receptor
H Osaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Pairwise interactions between neuronal α7 acetylcholine receptors and α-conotoxin PnIB
PA Quiram et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Mapping the conformational wave of acetylcholine receptor channel gating
C Grosman et al.
NATURE (2000)
Hydrophobic pairwise interactions stabilize α-conotoxin MI in the muscle acetylcholine receptor binding site
N Bren et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome
HL Wang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2000)