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David Hassel et al.
CIRCULATION (2008)
Spatiotemporal dynamics of β-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes -: Role of Phosphodiesterases
Jerome Leroy et al.
CIRCULATION RESEARCH (2008)
Homozygous Missense N629D hERG (KCNH2) Potassium Channel Mutation Causes Developmental Defects in the Right Ventricle and Its Outflow Tract and Embryonic Lethality
Guo Qi Teng et al.
CIRCULATION RESEARCH (2008)
Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome
Harinath Sale et al.
CIRCULATION RESEARCH (2008)
Ligand structural aspects of hERG channel blockade
Alex M. Aronov
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)
Kv11.1 channel subunit composition includes MinK and varies developmentally in mouse cardiac muscle
Xun Wang et al.
DEVELOPMENTAL DYNAMICS (2008)
Stimulation of N-terminal truncated isoform of androgen receptor stabilizes human ether-a-go-go-related gene-encoded potassium channel protein via activation of extracellular signal regulated kinase 1/2
Zhi-Yuan Wu et al.
ENDOCRINOLOGY (2008)
Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model
Torben Peitersen et al.
HEART RHYTHM (2008)
Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome
Chinmay Patel et al.
HEART RHYTHM (2008)
Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation
Zahurul A. Bhuiyan et al.
HEART RHYTHM (2008)
In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig
Rie Schultz Hansen et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2008)
Modeling the hERG potassium channel in a phospholipid bilayer: Molecular dynamics and drug docking studies
Matteo Masetti et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling
Sarah L. Wynia-Smith et al.
JOURNAL OF GENERAL PHYSIOLOGY (2008)
A-kinase anchoring protein targeting of protein kinase a and regulation of HERG channels
Yan Li et al.
JOURNAL OF MEMBRANE BIOLOGY (2008)
A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome
Qiuming Gong et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
Delayed-rectifier potassium currents and the control of cardiac repolarization: Noble and Tsien 40 years after
Stanley Nattel
JOURNAL OF PHYSIOLOGY-LONDON (2008)
ERG voltage-gated K+ channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones
Mauro Pessia et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
hERG classification model based on a combination of support vector machine method and GRIND descriptors
Qiyuan Li et al.
MOLECULAR PHARMACEUTICS (2008)
Topological mapping of the asymmetric drug binding to the human ether-a-go-go-related gene product (HERG) potassium channel by use of tandem dimers
Toshihiko Myokai et al.
MOLECULAR PHARMACOLOGY (2008)
Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels
Mark J. Perrin et al.
MOLECULAR PHARMACOLOGY (2008)
One step at a time: endoplasmic reticulum-associated degradation
Shruthi S. Vembar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Preclinical Torsades-de-Pointes screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
Gary A. Gintant
PHARMACOLOGY & THERAPEUTICS (2008)
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
Jules C. Hancox et al.
PHARMACOLOGY & THERAPEUTICS (2008)
The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity
Saverio Gentile et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
hERG1 channel activators: A new anti-arrhythmic principle
Morten Grunnet et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)
Endoplasmic reticulum retention and rescue by heteromeric assembly regulate human ERG 1a/1b surface channel composition
Pallavi Phartiyal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
State dependent dissociation of HERG channel inhibitors
D. Stork et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Evaluation of zebrafish embryos as a model for assessing inhibition of hERG
S.W. Mittelstadt et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2007)
Progesterone regulates cardiac repolarization through a nongenomic pathway - An in vitro patch-clamp and computational modeling study
Hiroaki Nakamura et al.
CIRCULATION (2007)
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
Stephen B. Long et al.
NATURE (2007)
Activation Gating of hERG potassium channels - S6 glycines are not required as gating hinges
Rachael M. Hardman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular driving forces determining potassium channel slow inactivation
Julio F. Cordero-Morales et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Impact of ancillary subunits on ventricular repolarization
Geoffrey W. Abbott et al.
JOURNAL OF ELECTROCARDIOLOGY (2007)
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2
Il-Ha Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Phosphatidylinositol 4,5-bisphosphate interactions with the HERG K+ channel
Jin-Song Bian et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Common genetic variation in KCNH2 is associated with QT interval duration -: The framingham heart study
Christopher Newton-Cheh et al.
CIRCULATION (2007)
Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator
Matthew Perry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
VEGFR-1 (FLT-1), β1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia:: role in cell migration and clinical outcome
Serena Pillozzi et al.
BLOOD (2007)
Co-chaperone FKBP38 promotes HERG trafficking
Valerie E. Walker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human Ether-a-go-go-related potassium channel
M. Zhang et al.
MOLECULAR PHARMACOLOGY (2007)
Drug block of the hERG potassium channel: Insight from modeling
Phillip J. Stansfeld et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
Does Tpeak-Tend provide an index of transmural dispersion of repotarization?
Charles Antzelevitch et al.
HEART RHYTHM (2007)
Activation of ERG2 potassium channels by the diphenylurea NS1643
Pernille Elmedyb et al.
NEUROPHARMACOLOGY (2007)
Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
Nathalie Gaborit et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Zebrafish model for human long QT syndrome
Rima Arnaout et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome
Qiuming Gong et al.
CIRCULATION (2007)
Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-Binding domain during oxidative stress
Chinavenmeni S. Velu et al.
BIOCHEMISTRY (2007)
Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol
Ravi C. Balijepalli et al.
CHANNELS (2007)
Recent advances in understanding sex differences in cardiac repolarization
Andrew F. James et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2007)
Understanding hERG inhibition with QSAR models based on a one-dimensional molecular representation
David J. Diller et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)
Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart
Rie Schultz Hansen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Mechanism of block of the hERG K+ channel by the scorpion toxin CnErg1
Adam P. Hill et al.
BIOPHYSICAL JOURNAL (2007)
Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes
Jun Guo et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits
S. L. Cockerill et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Probing the outer mouth structure of the hERG channel with peptide toxin footprinting and molecular modeling
Gea-Ny Tseng et al.
BIOPHYSICAL JOURNAL (2007)
Mutational analysis of block and facilitation of HERG current by A class III anti-arrhythmic agent, nifekalant
Yukio Hosaka et al.
CHANNELS (2007)
Development, interpretation and temporal evaluation of a global QSAR of hERG electrophysiology screening data
Claire L. Gavaghan et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)
Heteromeric assembly of human ether-a-go-go-related gene (hERG) 1a/1b channels occurs cotranslationally via N-terminal interactions
Pallavi Phartiyal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Long QT syndrome and pregnancy
Rahul Seth et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)
Dispersion of repolarization in canine ventricle and the electrocardiographic T wave:: Tp-e interval does not reflect transmural dispersion
Tobias Opthof et al.
HEART RHYTHM (2007)
HERG is protected from pharmacological block by α-1,2-glucosyltransferase function
Tadashi Nakajima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Molecular dynamics and continuum electrostatics studies of inactivation in the HERG potassium channel
Ramzi Kutteh et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2007)
Interaction simulation of hERG K+ channel with its specific BeKm-1 peptide:: Insights into the selectivity of molecular recognition
Hong Yi et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Tarantula toxins interacting with voltage sensors in potassium channels
Kenton J. Swartz
TOXICON (2007)
ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord
Francesco Furlan et al.
JOURNAL OF NEUROSCIENCE (2007)
Sphingolipid metabolite ceramide causes metabolic perturbation contributing to HERG K+ channel dysfunction
Yunlong Bai et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
The S631A mutation causes a mechanistic switch in the block of hERG channels by CnErg1
Adam P. Hill et al.
BIOPHYSICAL JOURNAL (2007)
Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions
K. H. W. J. Ten Tusscher et al.
PHYSICS IN MEDICINE AND BIOLOGY (2006)
Modulation of HERG gating by a charge cluster in the N-terminal proximal domain
J. B. Saenen et al.
BIOPHYSICAL JOURNAL (2006)
Muscarinic regulation of ether-a-go-go-related gene K+ currents in interstitial cells of Cajal
Catherine M. McKay et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
K+ channels involved in contractility of rabbit small intestine
V. Lamarca et al.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2006)
Complex functional interaction between integrin receptors and ion channels
Annarosa Arcangeli et al.
TRENDS IN CELL BIOLOGY (2006)
Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers
Alex M. Aronov
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Linkage between 'disruption of inactivation' and 'reduction of K+ selectivity' among hERG mutants in the S5-P linker region
Gea-Ny Tseng
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Mallotoxin is a novel human Ether-a-go-go-related gene (hERG) potassium channel activator
Haoyu Zeng et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Drug-induced long QT syndrome:: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine
S. Rajamani et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs
L. Fulop et al.
ACTA PHYSIOLOGICA (2006)
Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner
Makoto Ohmoto et al.
CHEMICAL SENSES (2006)
Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623[N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N′-(3′-trifluoromethylphenyl)urea]
Rie Schultz Hansen et al.
MOLECULAR PHARMACOLOGY (2006)
C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3ε
Chi-un Choe et al.
HUMAN MOLECULAR GENETICS (2006)
Restoring depressed HERG K+ channel function as a mechanism for insulin treatment of abnormal QT prolongation and associated arrhythmias in diabetic rabbits
Yiqiang Zhang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)
Integration of calcium with the signaling network in cardiac myocytes
Marcus C. Schaub et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)
Dynamic responses of single cardiomyocytes to graded ischemia studied by oxygen clamp in on-chip picochambers
Vladimir Ganitkevich et al.
CIRCULATION RESEARCH (2006)
Temperature dependence of human ether-a-go-go-related gene K+ currents
Jamie I. Vandenberg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Allelic dropout in long QT syndrome genetic testing: A possible mechanism underlying false-negative results
David J. Tester et al.
HEART RHYTHM (2006)
In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation
David J. Milan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)
Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges
Holly A. Kuzmiak et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Na+ permeation and block of hERG potassium channels
Hongying Gang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2006)
Effect of S5P α-helix charge mutants on inactivation of hERG K+ channels
C. E. Clarke et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
In silico classification of hERG channel blockers: a knowledge-based strategy
Elodie Dubus et al.
CHEMMEDCHEM (2006)
A novel hypothesis for the binding mode of HERG channel blockers
H Choe et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a′-go-go-related gene (hERG) K+ channel
T Ferrer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Quantitative structure-activity relationship studies on inhibition of HERG potassium channels
Katsumi Yoshida et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)
Species diversity and peptide toxins blocking selectivity of ether-a-go-go-related gene subfamily K+ channels in the central nervous system
R Restano-Cassulini et al.
MOLECULAR PHARMACOLOGY (2006)
Molecular determinants of hERG channel block
K Kamiya et al.
MOLECULAR PHARMACOLOGY (2006)
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies
R Farid et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
A QSAR model of hERG binding using a large, diverse, and internally consistent training set
M Seierstad et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2006)
Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects - A simulation study
H Itoh et al.
CIRCULATION JOURNAL (2006)
Rac GTPase signaling through the PP5 protein phosphatase
S Gentile et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
hERG potassium channels and cardiac arrhythmia
MC Sanguinetti et al.
NATURE (2006)
Synthesis of the first sulfur-35-labeled hERG radioligand
CE Raab et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
An accurate and interpretable Bayesian classification model for prediction of hERG liability
Hongmao Sun
CHEMMEDCHEM (2006)
Class III effects of dofetilide and arrhythmias are modulated by [K+]O in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium
J Ducroq et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
A voltage-driven switch for ion-independent signaling by ether-a-go-go K+ channels
AP Hegle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome
QM Gong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Effects of TRH on heteromeric rat erg1a/1b K+ channels are dominated by the rerg1b subunit
NM Kirchberger et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Mechanism of action of a novel human ether-a-go-go-related gene channel activator
O Casis et al.
MOLECULAR PHARMACOLOGY (2006)
Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs
M Perry et al.
MOLECULAR PHARMACOLOGY (2006)
Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism
CL Anderson et al.
CIRCULATION (2006)
Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3
Gottlieb Maier et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2006)
Functional significance of KCNH2 (HERG) K897T polymorphism for cardiac repolarization assessed by analysis of T-wave morphology
EH Linna et al.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (2006)
Genetic testing in the long QT syndrome - Development and validation of an efficient approach to genotyping in clinical practice
C Napolitano et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
Atorvastatin therapy increases heart rate variability, decreases QT variability, and shortens QTc interval duration in patients with advanced chronic heart failure
B Vrtovec et al.
JOURNAL OF CARDIAC FAILURE (2005)
Tryptophan scanning mutagenesis of the HERG K+ channel:: the S4 domain is loosely packed and likely to be lipid exposed
RN Subbiah et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
The endocrine function of the heart
MF McGrath et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2005)
Compartmentalization of adenylate cyclase and cAMP signalling
DMF Cooper
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Dynamic conformational changes of extracellular S5-P linkers in the hERG channel
M Jiang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Downregulation of the HERG (KCNH2) K+ channel by ceramide:: evidence for ubiquitin-mediated lysosomal degradation
H Chapman et al.
JOURNAL OF CELL SCIENCE (2005)
Tpeak-Tend interval as an index of global dispersion of ventricular repolarization:: Evaluations using monophasic action potential mapping of the epi- and endocardium in swine
YL Xia et al.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2005)
Rote of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes
C Antzelevitch
HEART RHYTHM (2005)
Expression pattern of the Ether-A-Go-Go-Related (ERG) family proteins in the adult mouse central nervous system: Evidence for coassembly of different subunits
L Guasti et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines
A Masi et al.
BRITISH JOURNAL OF CANCER (2005)
Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel
M Zhang et al.
JOURNAL OF MEMBRANE BIOLOGY (2005)
Molecular physiology of cardiac repolarization
JM Nerbonne et al.
PHYSIOLOGICAL REVIEWS (2005)
Diabetes, glucose level, and risk of sudden cardiac death
X Jouven et al.
EUROPEAN HEART JOURNAL (2005)
High-throughput assay for small molecules that modulate zebrafish embryonic heart rate
CG Burns et al.
NATURE CHEMICAL BIOLOGY (2005)
Restricting excessive cardiac action potential and QT prolongation -: A vital role for IKs in human ventricular muscle
N Jost et al.
CIRCULATION (2005)
Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve
J Silva et al.
CIRCULATION (2005)
Modelling of short QT syndrome in a heterogeneous model of the human ventricular wall
DL Weiss et al.
EUROPACE (2005)
KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome
L Crotti et al.
CIRCULATION (2005)
Modulation of IKr inactivation by mutation N588K in KCNH2:: A link to arrhythmogenesis in short QT syndrome
JM Cordeiro et al.
CARDIOVASCULAR RESEARCH (2005)
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
SB Long et al.
SCIENCE (2005)
Voltage sensor of kv1.2: Structural basis of electromechanical coupling
SB Long et al.
SCIENCE (2005)
Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37°C and 42°C
JQ Guo et al.
HEART RHYTHM (2005)
Refining detection of drug-induced proarrhythmia: QT interval and TRIaD
RR Shah et al.
HEART RHYTHM (2005)
Transient silent ischemia after percutaneous transluminal coronary angioplasty manifested with a bizarre electrocardiogram
H Özhan et al.
JOURNAL OF ELECTROCARDIOLOGY (2005)
Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization
A Akhavan et al.
JOURNAL OF CELL SCIENCE (2005)
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors
M Tobita et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Evaluation of a high-throughput fluorescence assay method for hERG potassium channel inhibition
A Dorn et al.
JOURNAL OF BIOMOLECULAR SCREENING (2005)
Human ether-a-go-go-related gene 1 channels are physically linked to β1 integrins and modulate adhesion-dependent signaling
A Cherubini et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway
QM Gong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pentamidine reduces hERG expression to prolong the QT interval
JS Cordes et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Solution structure of APETx1 from the sea anemone Anthopleura elegantissima:: A new fold for an HERG toxin
B Chagot et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)
Common variants in myocardial ion channel genes modify the QT interval in the general population -: Results from the KORA study
A Pfeufer et al.
CIRCULATION RESEARCH (2005)
Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells
I Kim et al.
JOURNAL OF APPLIED PHYSIOLOGY (2005)
Autonomic control of cardiac action potentials - Role of potassium channel kinetics in response to sympathetic stimulation
C Terrenoire et al.
CIRCULATION RESEARCH (2005)
Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome
T Rossenbacker et al.
CIRCULATION (2005)
Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins
JS Rougier et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)
Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel
JS Kang et al.
MOLECULAR PHARMACOLOGY (2005)
Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating
DR Piper et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Greater than the sum of its parts: Combining models for useful ADMET prediction
SE O'Brien et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
HERG channel (dys)function revealed by dynamic action potential clamp technique
G Berecki et al.
BIOPHYSICAL JOURNAL (2005)
Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways
SH Keller et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2005)
Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil
T Aiba et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)
Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs
SF Zhou et al.
CLINICAL PHARMACOKINETICS (2005)
Mechanisms of Disease: beta-adrenergic receptors - alterations in signal transduction and pharmacogenomics in heart failure
DS Feldman et al.
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE (2005)
Pentamidine-induced long QT syndrome and block of hERG trafficking
YA Kuryshev et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Unique interaction of scorpion toxins with the hERG channel
YV Korolkova et al.
JOURNAL OF MOLECULAR RECOGNITION (2004)
Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome
A Khositseth et al.
HEART RHYTHM (2004)
A model for identifying HERG K+ channel blockers
AM Aronov et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents
G Gessner et al.
MOLECULAR PHARMACOLOGY (2004)
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells
RB Clark et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
Short QT syndrome:: Pharmacological treatment
F Gaita et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Impairment of HERG K+ channel function by tumor necrosis factor-α -: Role of reactive oxygen species as a mediator
JX Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Expression and role of the ether-a-go-go-related (MERG1A) potassium-channel protein during preimplantation mouse development
NJ Winston et al.
BIOLOGY OF REPRODUCTION (2004)
A model for human ventricular tissue
KHWJ ten Tusscher et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
Physicochemical features of the hERG channel drug binding site
D Fernandez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Drug therapy: Drug-induced prolongation of the QT interval
DM Roden
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig
AA Fossa et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Differential regulation of the slow and rapid components of guinea-pig cardiac delayed rectifier K+ channels by hypoxia
LC Hool
JOURNAL OF PHYSIOLOGY-LONDON (2004)
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells
E Lastraioli et al.
CANCER RESEARCH (2004)
KvLQT1 modulates the distribution and biophysical properties of HERG -: A novel α-subunit interaction between delayed rectifier currents
JR Ehrlich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sudden death associated with short-QT syndrome linked to mutations in HERG
R Brugada et al.
CIRCULATION (2004)
In silico study of action potential and QT interval shortening due to loss of inactivation of the cardiac rapid delayed rectifier potassium current
HG Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
An intronic mutation causes long QT syndrome
GM Vincent et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Occurrence of notched T wave in healthy family members with the long QT interval syndrome
T Novotny et al.
AMERICAN JOURNAL OF CARDIOLOGY (2004)
Protein domains correlate strongly with exons in multiple eukaryotic genomes - evidence of exon shuffling?
MY Liu et al.
TRENDS IN GENETICS (2004)
A computational model of the human left-ventricular epicardial myocyte
V Iyer et al.
BIOPHYSICAL JOURNAL (2004)
Muscarinic modulation of erg potassium current
W Hirdes et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia
CI Petersen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Structural determinants of HERG channel block by clofilium and ibutilide
M Perry et al.
MOLECULAR PHARMACOLOGY (2004)
Gating charges in the activation and inactivation processes of the hERG channel
M Zhang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel
RN Subbiah et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X)
D Thomas et al.
CARDIOVASCULAR RESEARCH (2004)
Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by α1A-adrenoceptors
D Thomas et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2004)
Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation
T Sasano et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
Biogenesis of CFTR and other polytopic membrane proteins: New roles for the ribosome-translocon complex
H Sadlish et al.
JOURNAL OF MEMBRANE BIOLOGY (2004)
Mechanisms of arsenic-induced prolongation of cardiac repolarization
E Ficker et al.
MOLECULAR PHARMACOLOGY (2004)
Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels
PJS Chiu et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2004)
Current views on scorpion toxins specific for K+-channels
RCR de la Vega et al.
TOXICON (2004)
Biology of cardiac arrhythmias - Ion channel protein trafficking
BP Delisle et al.
CIRCULATION RESEARCH (2004)
Molecular analysis of PIP2 regulation of HERG and IKr
JS Bian et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
Conserved gating hinge in ligand- and voltage-dependent K+ channels
E Magidovich et al.
BIOCHEMISTRY (2004)
Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels
BD Anson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits
EMC Jones et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Rb+ flux through hERG channels affects the potency of channel blocking drugs:: Correlation with data obtained using a high-throughput Rb+ efflux assay
S Rezazadeh et al.
JOURNAL OF BIOMOLECULAR SCREENING (2004)
Zebrafish embryos express an orthologue of HERG and are sensitive toward a range and are of QT-prolonging drugs inducing severe arrhythmia
U Langheinrich et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Gating of Shaker-type channels requires the flexibility of S6 caused by prolines
AJ Labro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: Potassium channels
GA Gutman et al.
PHARMACOLOGICAL REVIEWS (2003)
Ethnic differences in cardiac potassium channel variants: Implications for genetic susceptibility to sudden cardiac death and genetic testing for congenital long QT syndrome
MJ Ackerman et al.
MAYO CLINIC PROCEEDINGS (2003)
Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system
M Papa et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2003)
Structure of the HERG K+ channel S5P extracellular linker -: Role of an amphipathic α-helix in C-type inactivation
AM Torres et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of a COOH-terminal segment involved in maturation and stability of human ether-a-go-go-related gene potassium channels
A Akhavan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1
K Angelo et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2003)
Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C
BP Delisle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structural basis for modulation and agonist specificity of HCN pacemaker channels
WN Zagotta et al.
NATURE (2003)
Gating currents associated with intramembrane charge displacement in HERG potassium channels
DR Piper et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Functional roles of an ERG current isolated in cerebellar Purkinje neurons
T Sacco et al.
JOURNAL OF NEUROPHYSIOLOGY (2003)
Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG)
KJ Paavonen et al.
CARDIOVASCULAR RESEARCH (2003)
Prediction of hERG potassium channel affinity by traditional and hologram QSAR methods
GM Keserü
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin
JT Milnes et al.
FEBS LETTERS (2003)
A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization
CR Bezzina et al.
CARDIOVASCULAR RESEARCH (2003)
Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein
D Thomas et al.
CARDIOVASCULAR RESEARCH (2003)
APETx1, a new toxin from the sea anemone Anthopleura elegantissima, blocks voltage-gated human ether-a-go-go related gene potassium channels
S Diochot et al.
MOLECULAR PHARMACOLOGY (2003)
The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels
N Alagem et al.
BIOPHYSICAL JOURNAL (2003)
Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel hERG
E Ficker et al.
CIRCULATION RESEARCH (2003)
Crystal structure of the potassium channel KirBac1.1 in the closed state
AL Kuo et al.
SCIENCE (2003)
Saxitoxin is a gating modifier of hERG K+ channels
JX Wang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes
J Liu et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
Expression and function of KCNH2 (HERG) in the human jejunum
AM Farrelly et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches
RA Pearlstein et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Risk stratification in the long-QT syndrome
SG Priori et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1
M Zhang et al.
BIOPHYSICAL JOURNAL (2003)
Sequence-function analysis of the K+-Selective family of ion channels using a comprehensive alignment and the KcsA channel structure
RT Shealy et al.
BIOPHYSICAL JOURNAL (2003)
X-ray structure of a voltage-dependent K+ channel
YX Jiang et al.
NATURE (2003)
Impairment of human ether-a-Go-Go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia -: Similar phenotypes but different mechanisms
YQ Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells
D Gómez-Varela et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
ERG K+ channels modulate the electrical and contractile activities of gallbladder smooth muscle
E Parr et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Expression of the ether-a-go-go (ERG) potassium channel in smooth muscle of the equine gastrointestinal tract and influence on activity of jejunal smooth muscle
JD Lillich et al.
AMERICAN JOURNAL OF VETERINARY RESEARCH (2003)
Is restoration of intracellular trafficking clinically feasible in the long QT syndrome?: The example of HERG mutations
ES Kaufman et al.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2003)
Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the Long-QT syndrome
K Takenaka et al.
CIRCULATION (2003)
C-terminal domains implicated in the functional surface expression of potassium channels
M Jenke et al.
EMBO JOURNAL (2003)
Interaction between tetraethylammonium and permeant cations at the inactivation gate of the HERG potassium channel
H Shimizu et al.
JAPANESE JOURNAL OF PHYSIOLOGY (2003)
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients
LH Curtis et al.
AMERICAN JOURNAL OF MEDICINE (2003)
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells
O Crociani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel -: Potential role of a conserved amino acid substitution in the S4 region
F Shoeb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity
YQ Zhang et al.
FEBS LETTERS (2003)
Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: Importance of triangulation, reverse use dependence, and instability
LM Hondeghem et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2003)
ERG K+ currents regulate pacemaker activity in ICC
YH Zhu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits
XK Liu et al.
CARDIOVASCULAR RESEARCH (2003)
Roles of L-type Ca2+ and delayed-rectifier K+ currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model
Y Kurata et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241
G Gessner et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Functionally-distinct proton-binding in HERG suggests the presence of two binding sites
GCL Bett et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2003)
T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity
M Yamaguchi et al.
CLINICAL SCIENCE (2003)
A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency
A Paulussen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Interaction with GM130 during HERG ion channel trafficking - Disruption by type 2 congenital long QT syndrome mutations
ECR Roti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides
M Corona et al.
FEBS LETTERS (2002)
New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1
YV Korolkova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Structural and functional role of the extracellular S5-P linker in the HERG potassium channel
J Liu et al.
JOURNAL OF GENERAL PHYSIOLOGY (2002)
Energetics of pore opening in a voltage-gated K+ channel
O Yifrach et al.
CELL (2002)
Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels
J Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors
S Pillozzi et al.
LEUKEMIA (2002)
Functional and molecular identification of ERG channels in murine portal vein myocytes
S Ohya et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Toward a pharmacophore for drugs inducing the long QT syndrome:: Insights from a CoMFA study of HERG K+ channel blockers
A Cavalli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women
E Pietilä et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Defective human ether-a-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus
S Kupershmidt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Role of glycosylation in cell surface expression and stability of HERG potassium channels
QM Gong et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
Expression and coassociation of ERG1, KCNQ1, and KCNE1 potassium channel proteins in horse heart
MR Finley et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
How to correct the QT interval for the effects of heart rate in clinical studies
P Davey
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2002)
Pharmacological rescue of human K+ channel long-QT2 mutations -: Human ether-a-go-go-related gene rescue without block
S Rajamani et al.
CIRCULATION (2002)
Scanning the intracellular S6 activation gate in the shaker K+ channel
DH Hackos et al.
JOURNAL OF GENERAL PHYSIOLOGY (2002)
Crystal structure and mechanism of a calcium-gated potassium channel
YX Jiang et al.
NATURE (2002)
Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells
GAM Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels
M Tristani-Firouzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule
L Pardo-Lopez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel
S Ekins et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Regulation of an ERG K+ current by Src tyrosine kinase
FS Cayabyab et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity
A Kagan et al.
EMBO JOURNAL (2002)
A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current.: Is MiRP1 the missing link?
M Weerapura et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Histidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo related gene-1 K+ channels confer sensitivity to reactive oxygen species
A Pannaccione et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Atria-sinus interaction demonstrated by blockade of the rapid delayed rectifier current
EE Verheijck et al.
CIRCULATION (2002)
The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations
E Ficker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle
S Ohya et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Rapid component IKr of the guinea-pig cardiac delayed rectifier K+ current is inhibited by β1-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways
CA Karle et al.
CARDIOVASCULAR RESEARCH (2002)
Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
SO Marx et al.
SCIENCE (2002)
Seven-transmembrane-spanning receptors and heart function
HA Rockman et al.
NATURE (2002)
Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel
PM Snyder et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mapping the receptor site for ergtoxin, a specific blocker of ERG channels
L Pardo-López et al.
FEBS LETTERS (2002)
Effects of premature stimulation on HERG K+ channels
Y Lu et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
HERG K+ channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate
JS Bian et al.
CIRCULATION RESEARCH (2001)
Tight steric closure at the intracellular activation gate of a voltage-gated K+ channel
D del Camino et al.
NEURON (2001)
Drug block of Iκr:: Model systems and relevance to human arrhythmias
T Yang et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2001)
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle
T Imai et al.
ACTA PHYSIOLOGICA SCANDINAVICA (2001)
[3H]dofetilide binding to HERG transfected membranes:: a potential high throughput preclinical screen
K Finlayson et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Development and evaluation of high throughput functional assay methods for hERG potassium channel
WM Tang et al.
JOURNAL OF BIOMOLECULAR SCREENING (2001)
Long-term modulation of HERG channel gating in hypoxia
L Fontana et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis
R Mazhari et al.
CIRCULATION RESEARCH (2001)
Testosterone-mediated modulation of HERG blockade by proarrhythmic agents
YM Shuba et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Functional characterization of the C-terminus of the human ether-a-go-go-related gene K+ channel (HERG)
E Aydar et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
MinK-related peptide 1 -: A β subunit for the HCN ion channel subunit family enhances expression and speeds activation
H Yu et al.
CIRCULATION RESEARCH (2001)
MinK-related peptide 1 associates with Kv4.2 and modulates its gating function -: Potential role as β subunit of cardiac transient outward channel?
M Zhang et al.
CIRCULATION RESEARCH (2001)
Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2
J Cui et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death
CE Clancy et al.
CARDIOVASCULAR RESEARCH (2001)
An ERG channel inhibitor from the scorpion Buthus eupeus
YV Korolkova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
HERG K+ channels activation during β1 integrin-mediated adhesion to fibronectin induces an up-regulation of αvβ3 integrin in the preosteoclastic leukemia cell line FLG 29.1
G Hofmann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
[3H]Dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?
K Finlayson et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Glucose- and arginine-induced insulin secretion by human pancreatic β-cells:: the role of HERG K+ channels in firing and release
B Rosati et al.
FASEB JOURNAL (2000)
Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome
E Ficker et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2000)
HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium
A Cherubini et al.
BRITISH JOURNAL OF CANCER (2000)
Probing the interaction between inactivation gating and D-sotalol block of HERG
H Numaguchi et al.
CIRCULATION RESEARCH (2000)
A structural basis for drug-induced long QT syndrome
JS Mitcheson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome
E Ficker et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)
Characterization of S818L mutation in HERG C-terminus in LQT2 -: Modification of activation-deactivation gating properties
T Nakajima et al.
FEBS LETTERS (2000)
A common polymorphism associated with antibiotic-induced cardiac arrhythmia
F Sesti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Spectrum of mutations in long-QT syndrome genes KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
I Splawski et al.
CIRCULATION (2000)
erg gene(s) expression during development of the nervous and muscular system of quail embryos
O Crociani et al.
MECHANISMS OF DEVELOPMENT (2000)
Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K+ channels
JL Wang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2000)
Cyclic AMP regulates the HERG K+ channel by dual pathways
J Cui et al.
CURRENT BIOLOGY (2000)
The dominant negative LQT2 mutation A561V reduces wild-type HERG expression
A Kagan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
The voltage sensor in voltage-dependent ion channels
F Bezanilla
PHYSIOLOGICAL REVIEWS (2000)
Novel gain-of-function mechanism in K+ channel-related Long-QT syndrome:: Altered gating and selectivity in the HERG1 N629D mutant
JP Lees-Miller et al.
CIRCULATION RESEARCH (2000)
Expression of distinct ERG proteins in rat, mouse, and human heart -: Relation to functional IKr channels
AL Pond et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Voltage-dependent structural interactions in the Shaker K+ channel
SK Tiwari-Woodruff et al.
JOURNAL OF GENERAL PHYSIOLOGY (2000)
Protein kinase C enhances the rapidly activating delayed rectifier potassium current, IKr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes
BM Heath et al.
JOURNAL OF PHYSIOLOGY-LONDON (2000)
Electrophysiological effects of dofetilide in an in vitro model of border zone between normal and ischemic/reperfused myocardium
R Rouet et al.
CIRCULATION (2000)
Effects of external acidosis on HERG current expressed in Xenopus oocytes
T Terai et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2000)
HERG-like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body
JL Overholt et al.
JOURNAL OF NEUROPHYSIOLOGY (2000)
Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
JS Mitcheson et al.
JOURNAL OF GENERAL PHYSIOLOGY (2000)
Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition
GK Dresser et al.
CLINICAL PHARMACOKINETICS (2000)
Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome
W Shimizu et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2000)
Idiopathic short QT interval: A new clinical syndrome?
I Gussak et al.
CARDIOLOGY (2000)
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