Journal
PHYSIOLOGICAL GENOMICS
Volume 39, Issue 3, Pages 131-140Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00050.2009
Keywords
biomedical research
Categories
Funding
- NIH [P01-CA-081534, R01-CA-134232, UL1-RR-025755, R01-LM-009533, UL1-RR-026314, R01-GM-077185, R01-GM-069589, R01-HL-073087]
Ask authors/readers for more resources
Payne PRO, Embi PJ, Sen CK. Translational informatics: enabling high-throughput research paradigms. Physiol Genomics 39: 131-140, 2009. First published September 8, 2009; doi: 10.1152/physiolgenomics.00050.2009.-A common thread throughout the clinical and translational research domains is the need to collect, manage, integrate, analyze, and disseminate large-scale, heterogeneous biomedical data sets. However, well-established and broadly adopted theoretical and practical frameworks and models intended to address such needs are conspicuously absent in the published literature or other reputable knowledge sources. Instead, the development and execution of multidisciplinary, clinical, or translational studies are significantly limited by the propagation of silos of both data and expertise. Motivated by this fundamental challenge, we report upon the current state and evolution of biomedical informatics as it pertains to the conduct of high-throughput clinical and translational research and will present both a conceptual and practical framework for the design and execution of informatics-enabled studies. The objective of presenting such findings and constructs is to provide the clinical and translational research community with a common frame of reference for discussing and expanding upon such models and methodologies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available