Journal
WATER RESEARCH
Volume 68, Issue -, Pages 510-521Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.watres.2014.09.056
Keywords
Coulombic interactions; Ion-exchange; Non-steroidal anti-inflammatory drugs; Pharmaceuticals; Urine source separation; van der Waals forces
Funding
- National Science Foundation Graduate Research Fellowship [DGE-1315138]
- NSF CAREER grant [CBET-1150790]
- Glick Scholarship at the University of Florida
- FRWA Curtis E. Lloyd Scholarship
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1150790, 1713704] Funding Source: National Science Foundation
Ask authors/readers for more resources
This research advances the knowledge of ion-exchange of four non-steroidal anti-inflammatory drugs (NSAIDs) - diclofenac (DCF), ibuprofen (IBP), ketoprofen (KTP), and naproxen (NPX) - and one analgesic drug paracetamol (PCM) - by strong-base anion exchange resin (AER) in synthetic ureolyzed urine. Freundlich, Langmuir, Dubinin -Astakhov, and Dubinin - Radushkevich isotherm models were fit to experimental equilibrium data using nonlinear least squares method. Favorable ion-exchange was observed for DCF, KTP, and NPX, whereas unfavorable ion-exchange was observed for IBP and PCM. The ion-exchange selectivity of the AER was enhanced by van der Waals interactions between the pharmaceutical and AER as well as the hydrophobicity of the pharmaceutical. For instance, the high selectivity of the AER for DCF was due to the combination of Coulombic interactions between quaternary ammonium functional group of resin and carboxylate functional group of DCF, van der Waals interactions between polystyrene resin matrix and benzene rings of DCF, and possibly hydrogen bonding between dimethylethanol amine functional group side chain and carboxylate and amine functional groups of DCF. Based on analysis of covariance, the presence of multiple pharmaceuticals did not have a significant effect on ion-exchange removal when the NSAIDs were combined in solution. The AER reached saturation of the pharmaceuticals in a continuous-flow column at varying bed volumes following a decreasing order of DCF > NPX approximate to KTP > IBP. Complete regeneration of the column was achieved using a 5% (m/m) NaCl, equal-volume water methanol solution. Results from multiple treatment and regeneration cycles provide insight into the practical application of pharmaceutical ion-exchange in ureolyzed urine using AER. (C) 2014 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available