Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 59, Issue 22, Pages 6693-6708Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/59/22/6693
Keywords
optical coherence tomography; blood flow imaging; blood flux; model-based spectral analysis
Funding
- National Institutes of Health [R01HL093140, R01EB009682, R01EY024158]
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In an optical coherence tomography (OCT) scan from a living tissue, red blood cells (RBCs) are the major source of backscattering signal from moving particles within microcirculatory system. Measuring the concentration and velocity of RBC particles allows assessment of RBC flux and flow, respectively, to assess tissue perfusion and oxygen/nutrition exchange rates within micro-structures. In this paper, we propose utilizing spectral estimation techniques to simultaneously quantify bi-directional particle flow and relative flux by spectral estimation of the received OCT signal from moving particles within capillary tubes embedded in tissue mimicking phantoms. The proposed method can be directly utilized for in vivo quantification of capillaries and microvessels. Compared to the existing methods in the literature that can either quantify flow direction or power, our proposed method allows simultaneous flow (velocity) direction and relative flux (power) estimation.
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