Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 59, Issue 13, Pages 3249-3260Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/59/13/3249
Keywords
thermal dose; optical properties; HIFU; thermal damage
Funding
- Boston University College of Engineering
- Engineering and Physical Sciences Research Council [EP/K02020X/1] Funding Source: researchfish
- EPSRC [EP/K02020X/1] Funding Source: UKRI
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This study examines the effectiveness of the thermal dose model in accurately predicting thermally induced optical property changes of ex vivo chicken breast between 500-1100 nm. The absorption coefficient, mu(a), and the reduced scattering coefficient, mu(s)', of samples are measured as a function of thermal dose over the range 50 degrees C-70 degrees C. Additionally, the maximum observable changes in mu(a) and mu(s)' are measured as a function of temperature in the range 50 degrees C-90 degrees C. Results show that the standard thermal dose model used in the majority of high-intensity focused ultrasound (HIFU) treatments is insufficient for modeling optical property changes, but that the isodose constant may be modified in order to better predict thermally induced changes. Additionally, results are presented that show a temperature dependence on changes in the two coefficients, with an apparent threshold effect occurring between 65 degrees C-70 degrees C.
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