Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 58, Issue 2, Pages 187-203Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/58/2/187
Keywords
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Funding
- Cancer Research UK
- Engineering and Physical Sciences Research Council
- MRC
- Department of Health (England) Centre Grant [C2536/A10337]
- UK Medical Research Council
- NIHR
- National Institutes of Health Research (NIHR) [NIHR/CS/009/009] Funding Source: National Institutes of Health Research (NIHR)
- Cancer Research UK [10337] Funding Source: researchfish
- Medical Research Council [G1100809, MC_U120081322] Funding Source: researchfish
- National Institute for Health Research [NIHR/CS/009/009] Funding Source: researchfish
- MRC [G1100809, MC_U120081322] Funding Source: UKRI
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Intra-tumour heterogeneity is a characteristic shared by all cancers. We explored the use of texture variables derived from images of [F-18]fluorothymidine-positron emission tomography (FLT-PET), thus notionally assessing the heterogeneity of proliferation in individual tumours. Our aims were to study the range of textural feature values across tissue types, verify the repeatability of these image descriptors and further, to explore associations with clinical response to chemotherapy in breast cancer patients. The repeatability of 28 textural descriptors was assessed in patients who had two FLT-PET scans prior to therapy using relative differences and the intra-class correlation coefficient (ICC). We tested associations between features at baseline and clinical response measured in 11 patients after three cycles of chemotherapy, and explored changes in FLT-PET at one week after the start of therapy. A subset of eight features was characterized by low variations at baseline (<+/- 30%) and high repeatability (0.7 <= ICC <= 1). The intensity distribution profile suggested fewer highly proliferating cells in lesions of non-responders compared to responders at baseline. A true increase in CV and homogeneity was measured in four out of six responders one week after the start of therapy. A number of textural features derived from FLT-PET are altered following chemotherapy in breast cancer, and should be evaluated in larger clinical trials for clinical relevance. Online supplementary data available from stacks. iop.org/PMB/58/187/mmedia
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