Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 56, Issue 22, Pages 7109-7125Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/56/22/008
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Funding
- US Army
- Gordon-CenSSIS program
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Cardiac computed tomography represents an important advancement in the ability to assess coronary vessels. The accuracy of these non-invasive imaging studies is limited, however, by the presence of calcium, since calcium blooming artifacts lead to an over-estimation of the degree of luminal narrowing. To address this problem, we have developed a unified decomposition-based iterative reconstruction formulation, where different penalty functions are imposed on dense objects (i.e. calcium) and soft tissue. The result is a quantifiable reduction in blooming artifacts without the introduction of new distortions away from the blooming observed in other methods. Results are shown for simulations, phantoms, ex vivo, and in vivo studies.
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