Viscoelasticity-based MR elastography of skeletal muscle

An in vivo multifrequency magnetic resonance elastography (MRE) protocol was developed for studying the viscoelastic properties of human skeletal muscle in different states of contraction. Low-frequency shear vibrations in the range of 25-62.5 Hz were synchronously induced into the femoral muscles of seven volunteers and measured in a cross-sectional view by encoding the fast-transverse shear wave component parallel to the muscle fibers. The so-called springpot model was used for deriving two viscoelastic constants, mu and alpha, from the dispersion functions of the complex shear modulus in relaxed and in loaded muscle. Representing the shear elasticity parallel to the muscle fibers, mu increased in all volunteers upon contraction from 2.68 +/- 0.23 kPa to 3.87 +/- 0.50 kPa. Also alpha varied with load, indicating a change in the geometry of the mechanical network of muscle from relaxation (alpha = 0.253 +/- 0.009) to contraction (alpha = 0.270 +/- 0.009). These results provide a reference for a future assessment of muscular dysfunction using rheological parameters.