Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 54, Issue 16, Pages N355-N365Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/54/16/N01
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Funding
- NCI NIH HHS [U24 CA110804-05, R01 CA121783, R01 CA121783-03, U24 CA110804] Funding Source: Medline
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Radiotracers labeled with high-energy positron emitters, such as those commonly used for positron emission tomography studies, emit visible light immediately following decay in a medium. This phenomenon, not previously described for these imaging tracers, is consistent with Cerenkov radiation and has several potential applications, especially for in vivo molecular imaging studies. Herein we detail a new molecular imaging tool, Cerenkov Luminescence Imaging, the experiments conducted that support our interpretation of the source of the signal, and proof-of-concept in vivo studies that set the foundation for future application of this new method.
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