Journal
VIRUS RESEARCH
Volume 209, Issue -, Pages 11-22Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2015.02.003
Keywords
Influenza viruses; Innate immunity; Interferon; RIG-I
Categories
Funding
- Wellcome Trust [087751/A/08/Z]
- Medical Research Council [G0700848]
- Medical Research Council [MR/K000241/1, G0700848] Funding Source: researchfish
- Wellcome Trust [101788/Z/13/Z] Funding Source: researchfish
- MRC [MR/K000241/1] Funding Source: UKRI
- Wellcome Trust [101788/Z/13/Z] Funding Source: Wellcome Trust
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The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
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