Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 53, Issue 22, Pages 6321-6336Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/53/22/004
Keywords
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Funding
- National Science Fund of China [60472004, 60551003]
- Ministry of Education of China [106143, NCET05-0828]
- USA National Institutes of Health [EB007288]
- ICRG of Hong Kong Polytechnic University [YG-79]
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Microcalcification is one of the earliest and main indicators of breast cancer. Because dual-energy digital mammography could suppress the contrast between the adipose and glandular tissues of the breast, it is considered a promising technique that will improve the detection of microcalcification. In dual-energy digital mammography, the imaged object is a human breast, while in calibration measurements only the phantoms of breast tissue equivalent materials are available. Consequently, the differences between phantoms and breast tissues will lead to calibration phantom errors. Based on the dual-energy imaging model, formulae of calibration phantom errors are derived in this paper. Then, this type of error is quantitatively analyzed using publicly available data and compared with other types of error. The results demonstrate that the calibration phantom error is large and dominant in dual-energy mammography, seriously decreasing calculation precision. Further investigations on the physical meaning of calibration phantom error reveal that the imaged objects with the same glandular ratio have identical calibration phantom error. Finally, an error correction method is proposed based on our findings.
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