Journal
VIRUS RESEARCH
Volume 209, Issue -, Pages 128-135Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2015.02.024
Keywords
Human RSV and human MPV; Fusion protein inhibitors and antibodies; Vaccines and antivirals
Categories
Funding
- Ministerio de Economia y Competitividad [SAF2012-31217]
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The Pneumovirinae fusion (F) protein mediates fusion of the virus and cell membrane, an essential step for entry of the viral genome in the cell cytoplasm and initiation of a new infectious cycle. Accordingly, potent inhibitors of virus infectivity have been found among antibodies and chemical compounds that target the Pneumovirinae F protein. Recent developments in structure-based vaccines have led to a deeper understanding of F protein antigenicity, unveiling new conformations and epitopes which should assist in development of efficacious vaccines. Similarly, structure-based studies of potent antiviral inhibitors have provided information about their mode of action and mechanisms of resistance. The advantages and disadvantages of the different options to battle against important pathogens, such as human respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are summarized and critically discussed in this review. (C) 2015 Elsevier B.V. All rights reserved.
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