Journal
VIRUS RESEARCH
Volume 210, Issue -, Pages 308-317Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2015.09.007
Keywords
Herpesviridae; Herpesvirus; HSV-1; Tegument; Assembly; Envelopment
Categories
Funding
- Australian National Health and Medical Research Council [632616]
- Westmead Millennium Foundation
- Westmead Charitable Trust
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One of the structural components of herpesviruses is a protein layer called the tegument. Several of the tegument proteins are highly conserved across the herpesvirus family and serve as a logical focus for defining critical interactions required for viral assembly. A number of studies have helped to elucidate a role for conserved tegument proteins in the process of secondary envelopment during the course of herpesviral assembly. This review highlights how these tegument proteins directly contribute to bridging the nucleocapsid and envelope of virions during secondary envelopment. (C) 2015 Elsevier B.V. All rights reserved.
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