Journal
PHYSICS AND CHEMISTRY OF LIQUIDS
Volume 53, Issue 3, Pages 293-306Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00319104.2014.961191
Keywords
sulfonamides; inverse Kirkwood-Buff integrals; preferential solvation; 1-propanol
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The preferential solvation parameters by 1-propanol of sulfadiazine, sulfamerazine and sulfamethazine in 1-propanol + water mixtures were derived from their solution thermodynamic properties by means of the inverse Kirkwood-Buff integrals method. These sulfonamides are sensitive to solvation effects, so the preferential solvation parameter delta x(1,3) is negative in water-rich and 1-propanol-rich mixtures but positive in intermediate compositions. It is possible that the hydrophobic hydration around aromatic rings and/or other non-polar groups plays a relevant role in the solvation in water-rich mixtures. The more solvation by 1-propanol in mixtures of similar composition could be due mainly to polarity effects and acidic behaviour of the sulfonamides in front to the more basic solvent 1-propanol. Otherwise, the more solvation by water in 1-propanol-rich mixtures could be due to basic behaviour of the sulfonamides in front to water, which is the more acidic solvent.
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