Journal
VIROLOGY
Volume 479, Issue -, Pages 657-671Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.01.025
Keywords
Plant virus; TMV; TuMV; RCNMV; PVX; Membranes; Cytoskeleton; Plasmodesmata; Viral replication complex; Movement protein
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Funding
- University of Strasbourg Institute of Advance Study (USIAS)
- French Agence National de la Recherche Scientifique (ANR, Plant-KBBE)
- Swiss National Science Foundation [31003A_140694]
- Swiss National Science Foundation (SNF) [31003A_140694] Funding Source: Swiss National Science Foundation (SNF)
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Replication and intercellular spread of viruses depend on host mechanisms supporting the formation, transport and turnover of functional complexes between viral genomes, virus-encoded products and cellular factors. To enhance these processes, viruses assemble and replicate in membrane-associated complexes that may develop into virus factories or viroplasms in which viral components and host factors required for replication are concentrated. Many plant viruses replicate in association with the cortical ER-actin network that is continuous between cells through plasmodesmata. The replication complexes can be highly organized and supported by network interactions between the viral genome and the virus-encoded proteins. Intracellular PD targeting of replication complexes links the process of movement to replication and provides specificity for transport of the viral genome by the virus-encoded movement proteins. The formation and trafficking of replication complexes and also the development and anchorage of replication factories involves important roles of the cortical cytoskeleton and associated motor proteins. (C) 2015 Elsevier Inc. All rights reserved.
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