Journal
VIROLOGY
Volume 482, Issue -, Pages 67-71Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.03.020
Keywords
USUV; WNV; Flavivirus; Susceptibility; Crossreactivity
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Funding
- Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA) [RTA-2011-0036, E_RTA2013-00013-C04-2014]
- PLATESA from Comunidad Autonoma de Madrid [P2013/ABI-2906]
- Network of Animal Disease Infectiology and Research-European Union [NADIR-EU-228394]
- Junta de Ampliacion de Estudios (JAE) doctoral fellowship from Spanish Research Council (CSIC)
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Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. In Europe, West Nile virus (WNV) outbreaks have dramatically increased in number and severity in recent years, with dozens of human and horse deaths and a high avian mortality across the continent. Besides WNV, the only clinically relevant mosquito-borne flavivirus detected so far in Europe has been the Usutu virus (USUV), which after being reported for the first time in Austria in 2001, quickly spread across Europe, causing a considerable number of bird deaths and neurological disorders in a few immuno-compromised patients. Even though USUV infects multiple avian species that develop antibodies, there is little information about USUV susceptibility, pathogenicity and cross-reactive immunity. Here, the susceptibility of suckling and adult mice to USUV infection and the induction of cross-protective immunity against WNV challenge have been addressed. (C) 2015 Elsevier Inc. All rights reserved.
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