Journal
VIROLOGY
Volume 485, Issue -, Pages 16-24Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2015.06.026
Keywords
Mastadenovirus; Skunk adenovirus; Whole genome sequence; Liver tropism
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN 41625-2013]
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Adenoviruses are a ubiquitous group of viruses that have been found in a wide range of hosts. A novel adenovirus from a skunk suffering from acute hepatitis was isolated and its DNA genome sequenced. The analysis revealed this virus to be a new member of the genus Mastadenovirus, with a genome of 31,848 bp in length containing 30 genes predicted to encode proteins, and with a G+C content of 49.0%. Global genomic organization indicated SkAdV-1 was similar in organization to bat and canine adenoviruses, and phylogenetic comparison suggested these viruses shared a common ancestor. SkAdV-1 demonstrated an ability to replicate in several mammalian liver cell lines suggesting a potential tropism for this virus. (C) 2015 Elsevier Inc. All rights reserved.
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