Journal
PHYSICAL REVIEW LETTERS
Volume 112, Issue 6, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.112.068101
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Funding
- National Science Foundation [DMS-0969417, EF-1038636, DGE-0966125]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0969417] Funding Source: National Science Foundation
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Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.
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