Journal
PHYSICAL REVIEW LETTERS
Volume 110, Issue 17, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.110.178103
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Funding
- Pew Scholars Award
- NIH [OD004690]
- Morgridge Family Stanford Graduate Fellowship
- Stanford Interdisciplinary Graduate Fellowship
- Natural Sciences and Engineering Research Council of Canada [NSERC PGS-D]
- EMBO
- Swiss National Science Foundation
- Stanford University Dean's Fellowship
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Changes in global DNA linking number can be accommodated by localized changes in helical structure. We have used single-molecule torque measurements to investigate sequence-specific strand separation and Z-DNA formation. By controlling the boundary conditions at the edges of sequences of interest, we have confirmed theoretical predictions of distinctive boundary-dependent backbending patterns in torque-twist relationships. Abrupt torque jumps are associated with the formation and collapse of DNA bubbles, permitting direct observations of DNA breathing dynamics. DOI: 10.1103/PhysRevLett.110.178103
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