Journal
PHYSICAL REVIEW LETTERS
Volume 110, Issue 1, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.110.018103
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Funding
- National Science Foundation [DMR-1006546]
- Harvard Materials Research Science and Engineering Center [DMR-0820484]
- U.S. Department of Energy [FG02-97ER25308]
- NIH [DK59588, DK083592]
- Foundation for Fundamental Research on Matter
- Netherlands Organization for Scientific Research
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1006546] Funding Source: National Science Foundation
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A hallmark of biopolymer networks is their sensitivity to stress, reflected by pronounced nonlinear elastic stiffening. Here, we demonstrate a distinct dynamical nonlinearity in biopolymer networks consisting of filamentous actin cross-linked by alpha-actinin-4. Applied stress delays the onset of relaxation and flow, markedly enhancing gelation and extending the regime of solidlike behavior to much lower frequencies. We show that this macroscopic network response can be accounted for at the single molecule level by the increased binding affinity of the cross-linker under load, characteristic of catch-bond-like behavior. DOI: 10.1103/PhysRevLett.110.018103
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