Journal
PHYSICAL REVIEW LETTERS
Volume 110, Issue 1, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.110.018101
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Funding
- National Institutes of Health Pioneer Award [DP1 OD000217, R01 GM085286, R01 GM085286-01S]
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Transcriptional networks across all domains of life feature a wide range of regulatory architectures. Theoretical models now make clear predictions about how key parameters describing those architectures modulate gene expression, and the ability to construct genetic circuits with tunable parameters enables precise tests of such models. We dissect gene regulation through DNA looping by tuning network parameters such as repressor copy number, DNA binding strengths, and loop length in both thermodynamic models and experiments. Our results help clarify the short-length mechanical properties of DNA. DOI: 10.1103/PhysRevLett.110.018101
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