Journal
VIRAL IMMUNOLOGY
Volume 28, Issue 1, Pages 32-41Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2014.0085
Keywords
-
Categories
Funding
- Department of Defense, Defense Threat Reduction Agency, Joint Science and Technology Office
Ask authors/readers for more resources
The rhesus macaque serves as an animal model for Ebola virus (EBOV) infection. A thorough understanding of EBOV infection in this species would aid in further development of filovirus therapeutics and vaccines. In this study, pathological and immunological data from EBOV-infected rhesus macaques are presented. Changes in blood chemistries, hematology, coagulation, and immune parameters during infection, which were consistently observed in the animals, are presented. In an animal that survived challenge, a delay was observed in the detection of viral RNA and inflammatory cytokines and chemokines which may have contributed to survival. Collectively, these data add to the body of knowledge regarding EBOV pathogenesis in rhesus macaques and emphasize the reproducibility of the rhesus macaque challenge model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available