Journal
PHYSICAL REVIEW LETTERS
Volume 104, Issue 22, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.104.225501
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Funding
- Helmholtz Association
- U.S. Department of Energy, Office of Basic Energy Sciences
- Lawrence Livermore National Laboratory ( LLNL) [W-7405- Eng-48, DE-AC52-07NA27344]
- Laboratory of Directed Research and Development Program of LLNL [05-SI-003]
- Deutsches Elektronen-Synchrotron
- DFG Cluster of Excellence at Munich center for Advanced Photonics
- Virtual Institute Program of Helmholtz Society
- Joachim Herz Stiftung
- Max Planck Society
- Swedish Research Council
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We reconstructed the 3D Fourier intensity distribution of monodisperse prolate nanoparticles using single-shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast x-ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the expansion-maximization-compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single-shot diffraction imaging of single biomolecules.
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