Journal
PHYSICAL REVIEW LETTERS
Volume 105, Issue 17, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.105.178102
Keywords
-
Categories
Funding
- Research Councils United Kingdom
Ask authors/readers for more resources
The synaptic coupling between neurons in neocortical networks is sufficiently strong so that relatively few synchronous synaptic pulses are required to bring a neuron from rest to the spiking threshold. However, such finite-amplitude effects of fluctuating synaptic drive are missed in the standard diffusion approximation. Here exact solutions for the firing-rate response to modulated presynaptic rates are derived for a neuron receiving additive excitatory and inhibitory synaptic shot noise with exponential amplitude distributions. The shot-noise description of the neuronal response to synaptic dynamics is shown to be richer and qualitatively distinct from that predicted by the diffusion approximation. It is also demonstrated how the framework developed here can be generalized to multiplicative shot noise so as to better capture effects of the inhibitory reversal potential.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available