Journal
PHYSICAL REVIEW LETTERS
Volume 103, Issue 1, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.103.018102
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Funding
- Israel Science Foundation (ISF)
- Canadian CHIR Program Innovative Technologies in Multidisciplinary Health Research Training.''
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We measured individual trajectories of fluorescently labeled telomeres in the nucleus of eukaryotic cells in the time range of 10(-2)-10(4)sec by combining a few acquisition methods. At short times the motion is subdiffusive with << r(2)>>similar to t(alpha) and it changes to normal diffusion at longer times. The short times diffusion may be explained by the reptation model and the transient diffusion is consistent with a model of telomeres that are subject to a local binding mechanism with a wide but finite distribution of waiting times. These findings have important biological implications with respect to the genome organization in the nucleus.
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