Journal
PHYSICAL REVIEW LETTERS
Volume 103, Issue 15, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.103.158102
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Funding
- Human Frontier Science Program [RGP0051/2003]
- European Commission FP6 Integrated Project EUROHEAR [LSHG-CT-2004-512063]
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Spontaneous mechanical oscillations occur in various types of biological systems where groups of motor molecules are elastically coupled to their environment. By using an optical trap to oppose the gliding motion of a single bead-tailed actin filament over a substrate densely coated with myosin motors, we mimicked this condition in vitro. We show that this minimal actomyosin system can oscillate spontaneously. Our finding accords quantitatively with a general theoretical framework where oscillatory instabilities emerge generically from the collective dynamics of molecular motors under load.
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