Journal
PHYSICAL REVIEW LETTERS
Volume 101, Issue 15, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.101.158101
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Funding
- U. S. Department of Energy
- Office of Basic Energy Sciences [DE-FG02-06ER46276]
- U. S. National Science Foundation
- Division of Materials Research [DMR-0520894]
- Alfred P. Sloan Foundation
- RIKEN
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We report the recording and reconstruction of x-ray diffraction patterns from single, unstained viruses, for the first time. By separating the diffraction pattern of the virus particles from that of their surroundings, we performed quantitative and high-contrast imaging of a single virion. The structure of the viral capsid inside a virion was visualized. This work opens the door for quantitative x-ray imaging of a broad range of specimens from protein machineries and viruses to cellular organelles. Moreover, our experiment is directly transferable to the use of x-ray free electron lasers, and represents an experimental milestone towards the x-ray imaging of large protein complexes.
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