Journal
VETERINARY MICROBIOLOGY
Volume 181, Issue 3-4, Pages 236-240Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2015.09.021
Keywords
Pathogenicity; Pseudorabies virus; Variant
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Funding
- Shanghai Municipal Natural Science Foundation [14ZR1448900]
- Shanghai city agriculture science and technology key project [1-7]
- National Nonprofit Institute Research Grant of CATAS-ITBB [2014JB02]
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Pseudorabies virus (PRV) causes Pseudorabies (PR), an economically important disease in domestic swine. PR outbreaks on pig farms caused by PRV variant strains in Bartha-K61-vaccinated pigs have resulted in considerable economic losses in China since 2011. In this study, the pathogenicity of the PRV variant JS-2012 strain to pigs was investigated by experimentally inoculating piglets of different ages in comparison with a classic virulent PRV SC strain. The JS-2012 strain caused an earlier onset of clinical signs and higher mortality in 15, 30, and 60-day-old pigs, as compared with a classic virulent PRV SC strain. The Bartha-K61 vaccination provided complete protection against challenge with classical virulent PRV, but only partial protection against challenge with the JS-2012 strain in piglets. In conclusion, the increased virulence of the PRV variant may have partly contributed to the PR outbreak in China. (C) 2015 Elsevier B.V. All rights reserved.
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