Journal
VETERINARY MICROBIOLOGY
Volume 177, Issue 1-2, Pages 87-94Publisher
ELSEVIER
DOI: 10.1016/j.vetmic.2015.02.020
Keywords
Cross-protection; Genotype; Porcine reproductive and respiratory syndrome virus; Vaccine
Categories
Funding
- Bio-industry Technology Development Program Ministry of Agriculture, Food and Rural Affairs, Republic of Korea [312027-3]
- Zoetis in APAC
- Research Institute for Veterinary Science (RIVS) from the College of Veterinary Medicine [550-20120102]
- BK 21 Plus Program for Creative Veterinary Science Research
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The objective of the present study was to determine the cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine against heterologous type 1 PRRSV challenge in growing pigs. The mean rectal temperature and respiratory score was significantly (P < 0.05) lower in vaccinated challenged pigs than in unvaccinated challenged pigs. Vaccination of pigs with type 2 PRRSV reduced the levels of type 1 PRRSV viremia after challenge with type 1 PRRSV. Vaccinated challenged pigs had significantly (P < 0.05) higher frequency of interferon-gamma secreting cells and lower levels of interleukin-10 compared to unvaccinated challenged pigs. Vaccination of pigs with the type 2 PRRSV effectively reduced the macroscopic and microscopic lung lesion and the type 1 PRRSV antigens within lung lesions in vaccinated challenged pigs. This study demonstrates partial cross-protection of a new type 2 PRRSV modified live vaccine against heterologous type 1 PRRSV challenge in growing pigs. (C) 2015 Elsevier B.V. All rights reserved.
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