Journal
PHYSICAL REVIEW E
Volume 83, Issue 3, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.83.031908
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Funding
- Spanish Government [BIO2008-01353, PR2009-0285, JC2009-00067]
- Spanish Junta de Andalucia [P07-FQM3163, P06-FQM1858]
- Basque Country
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Human DNA shows a complex structure with compositional features at many scales; the isochores-long DNA segments (similar to 10(5) bp) of relatively homogeneous guanine-cytosine (G + C) content-are the largest well-documented and well-analyzed compositional structures. However, we report here on the existence of a high-level compositional organization of isochores in the human genome. By using a segmentation algorithm incorporating the long-range correlations existing in human DNA, we find that every chromosome is composed of a few huge segments (similar to 10(7) bp) of relatively homogeneous G + C content, which become the largest compositional organization of the genome. Finally, we show evidence of the biological relevance of these superstructures, pointing to a large-scale functional organization of the human genome.
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