Precipitation in aqueous mixtures with addition of a strongly hydrophilic or hydrophobic solute

We examine phase separation in aqueous mixtures due to preferential solvation with a low-density solute (hydrophilic ions or hydrophobic particles). For hydrophilic ions, preferential solvation can stabilize water domains enriched with ions. This precipitation occurs above a critical solute density n(p) in wide ranges of the temperature and the average composition, where the mixture solvent would be in a one-phase state without solute. The volume fraction of precipitated domains tends to zero as the average solute density (n) over bar is decreased to n(p) or as the interaction parameter chi is decreased to a critical value chi(p). If we start with one-phase states with (n) over bar > n(p) or chi >chi(p), precipitation proceeds via homogeneous nucleation or via heterogeneous nucleation, for example, around suspended colloids. In the latter case, colloid particles are wrapped by thick wetting layers. We also predict a first-order prewetting transition for (n) over bar or chi slightly below n(p) or chi(p) for neutral colloids.