Journal
PHYSICAL REVIEW E
Volume 81, Issue 3, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.81.031906
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Funding
- NIH [P01GM078586]
- NSF [0822283]
- Division Of Physics
- Direct For Mathematical & Physical Scien [0822283] Funding Source: National Science Foundation
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Eukaryotic cells are capable of detecting small chemical gradients for a wide range of background concentrations. Ultimately, fluctuations place a limit on gradient sensing and recent work has focused on the role of stochastic receptor occupancy as one possible limiting factor. Here, we use a phenomenological approach to add spontaneous motility fluctuations to receptor noise and predict the directional statistics of eukaryotic chemotaxis. Specifically, an It diffusion equation with direction-dependent multiplicative noise is developed and analytically studied. We show that our approach can naturally accommodate recent experimental data for the chemotaxis of the social amoeba Dictyostelium.
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