Journal
PHYSICAL REVIEW E
Volume 80, Issue 3, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.80.030901
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Funding
- NIH [R01-GM082837-01A1]
- Department of Energy [DOE-2005-05818]
- National Science Foundation [082265]
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We analyze a system-level model for lytic repression of lambda phage in E. coli using reliability theory, showing that the repressor circuit comprises four redundant components whose failure mode is prophage induction. Our model reflects the specific biochemical mechanisms involved in regulation, including long-range cooperative binding, and its detailed predictions for prophage induction in E. coli under ultraviolet radiation are in good agreement with experimental data.
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