Journal
PHYSICAL REVIEW E
Volume 79, Issue 3, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.79.031925
Keywords
cellular biophysics; ice; molecular biophysics; proteins; solvent effects; surface phenomena; water
Categories
Funding
- Chinese Academy of Sciences
- National Basic Research Program of China [2007CB936000, 2007CB814800]
- Shanghai Leading Academic Discipline Project [B111]
- Shanghai Supercomputer Center China
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Recent experiments and numerical simulations have shown that the water molecules confined on the surfaces of some substrates, including the surfaces of cellular components in tissues and cells, form icelike ordered structures. If a protein folds in an environment with those icelike ordered water molecules, its behavior may be different from that in bulk water. Here, the effect of this ordered water environment on protein folding is studied by using an off-lattice Go $$($) over bar -like model. It is found that the ordered water environment significantly improves the native state stability and greatly speeds up the folding rate of the proteins.
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