Journal
PHYSICAL REVIEW E
Volume 78, Issue 4, Pages -Publisher
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.78.041908
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Funding
- Quantum Thermodynamics, U.S. Civil Research Development Foundation [ARP2-2647-Ye-05]
- U.S. DARPA [HR00110510057]
- National Center for Theoretical Sciences in Taiwan
- Academia Sinica (Taiwan) [AS-95TP-A07]
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We introduce an alternative way to study molecular evolution within well-established Hamilton-Jacobi formalism, showing that for a broad class of fitness landscapes it is possible to derive dynamics analytically within the 1/N accuracy, where N is the genome length. For a smooth and monotonic fitness function this approach gives two dynamical phases: smooth dynamics and discontinuous dynamics. The latter phase arises naturally with no explicite singular fitness function, counterintuitively. The Hamilton-Jacobi method yields straightforward analytical results for the models that utilize fitness as a function of Hamming distance from a reference genome sequence. We also show the way in which this method gives dynamical phase structure for multipeak fitness.
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