Journal
VACCINE
Volume 33, Issue 31, Pages 3650-3658Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2015.05.104
Keywords
Oral vaccine; Vaccine cost; Transgenic plant; Transient expression; Transplastomic plant; Edible crop; E antigen; Virus like particles
Categories
Funding
- CONACTINexico [CB-2008-01, 102109, CB-2010-01, 151818]
- FAI/UASLP/2015
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Chikungunya virus is an emerging pathogen initially found in East Africa and currently spread into the Indian Ocean Islands, many regions of South East Asia, and in the Americas. No licensed vaccines against this eminent pathogen are available and thus intensive research in this field is a priority. This review presents the current scenario on the developments of Chikungunya virus vaccines and identifies the use of genetic engineered plants to develop attractive vaccines. The possible avenues to develop plant-made vaccines with distinct antigenic designs and expression modalities are identified and discussed considering current trends in the field. (C) 2015 Elsevier Ltd. All rights reserved.
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