Journal
ARCHIVES OF VIROLOGY
Volume 160, Issue 10, Pages 2603-2609Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-015-2545-5
Keywords
Norovirus; Prevalence; Thailand; Genome recombination
Categories
Funding
- National Research University Project, Office of Higher Education Commission [WCU001-HR-57, WCU007-HR-57, WCU-58-006-HR]
- National Research Council of Thailand (NRCT)
- National Science and Technology Development Agency
- Chulalongkorn University Centenary Academic Development Project [CU56-HR01]
- Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University [RES560530093]
- Siam Cement Public Company Limited (SCG)
- MK Restaurant Group Public Company Limited
- King Chulalongkorn Memorial Hospital
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Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide. New strains emerge partly due to viral recombination. In Thailand, there is a lack of data on NoV recombinants among clinical isolates. We screened stool samples from pediatric diarrheal patients for norovirus by RT-PCR and found GII.4 to be the most prevalent genotype. Phylogenetic and SimPlot analyses detected seven intra-genogroup recombinant strains: three GII.21/GII.3, two GII.12/GII.3, and two GII.12/GII.1 recombinants. Maximum chi-square analysis indicated that all had similar breakpoints near the ORF1/ORF2 junction (p < 0.001), either slightly upstream within the C-terminus of RdRp or downstream within the N-terminal domain of VP1.
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